What category do experiments involving wild-type animal viruses administered to transgenic rodents fall under?

Experiments involving wild-type animal viruses administered to transgenic rodents fall under the category that requires Institutional Biosafety Committee (IBC) approval simultaneous with initiation due to the potential risks to the health and safety of the researchers, the animals, and the environment. Wild-type viruses can have unpredictable pathogenicity, and their effects on genetically modified organisms such as transgenic rodents can introduce complexities and unforeseen consequences.

In this context, IBC approval ensures that the proposed research has been thoroughly reviewed for safety and compliance with biosafety regulations. This oversight is essential to mitigate any biohazard risks associated with handling, breeding, or manipulating organisms that harbor wild-type viral agents, which could lead to adverse outcomes if the research is not adequately controlled.

The other options suggest scenarios that do not provide sufficient oversight or evaluation required for experiments dealing with the complexities of wild-type viruses in genetically engineered models, which is why they are not suitable in this context.